The Cure for FIP: Beyond the Hype (continued)
NOTHING BUT THE TRUTH
We end here our fact-based analysis of the Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis article. The references to quotes and studies are listed below, for you to read and further educate yourself, if you feel so inclined. You now have plenty of information to make up your minds next time someone flashes a catchy headline about the cure for FIP (generally followed with an appeal for more funding).
FIP research is needed. Research is a must. But FIP research should not be hijacked by any single person/team/school of thought. We need diversified, forward-thinking, cruelty-free research. Next time you donate or consider making a donation, demand accountability. There's more to research than make-believe stories and cute cat pictures.
Aurora Lambrecht, Bobbi Rosell, Fabienne Ridolfi, Kathleen Jack.
Notes and references:
• Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. http://journals.sagepub.com/doi/pdf/10.1177/1098612X17729626
• References to experimental studies linked to GC376 clinical trial:
- Kim Y, Liu H, Galasiti Kankanamalage AC, et al. Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor. PLOS Pathog 2016; 12: e1005531; 24 cats, 6 survivors.
- Pedersen NC, Eckstrand C, Liu H, et al. Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Vet Microbiol 2015; 175: 157–166. 11; 20 cats, one survivor.
- Pedersen NC, Liu H, Durden M, et al. Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection. Vet Immunol Immunopathol 2016; 171: 17–20; 63 cats, seven survivors.
- Pedersen NC, Liu H, Gandolfi B, et al. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. Vet Immunol Immunopathol 2014; 162: 33–40). 111 cats, no survivor.
FIP Diagnosis references:
- Hartmann K. et al. Comparison of Different Tests to Diagnose Feline Infectious Peritonitishttp://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2003.tb02515.x/pdf
- Addie D, et al. Feline infectious peritonitis. ABCD guidelines on prevention and management. J Feline Med Surg 2009; 11: 594-604. http://www.abcdcatsvets.org/feline-infectious-peritonitis/
• Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study, Legendre A. et al, http://www.frontiersin.org/articles/10.3389/fvets.2017.00007/full
• GC376 sourcing: https://www.medchemexpress.com/GC376.html.
• 39th Annual Winn Symposium – June 29, 2017 ‟Ending FIP – Is there Hope?" http://www.winnfelinefoundation.org/docs/default-source/symposium-transcripts/2018-winn-symposium-ending-fip-transcript.pdf